The Biochemistry of Cell Signalling

The Biochemistry of Cell Signalling

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'In-depth coverage of the principles of cell signalling... will be an essential purchase for researchers and teachers in this area.' -ChemBioChem'This useful production by Ernst Helmrich is beautifully presented by Oxford University Press. Each contribution is lucid, well illustrated and accompained by extensive reference lists... [a] labour of love... this is a solid enough reference book for the general research student, post-doc and senior investigator who needs to get a reasonable background to cell signalling... a very readable and useful book for background knowledge.' -Cell Biology International'Recommended for everyone working in the area of signal transduction research, who should keep this book at hand for when they want to clarify a particular mechanism or connection again, and to get quick access to the most important original papers and review articles.' -Angewandte ChemieThe Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-AŸ in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response.This gives cells time for DNA repair. p53 may also keep them arrested permanently, preventing proliferation of damaged cells. But p53 also plays a role in ... takes part in DNA repair. p53R2 is like a normal R2, but it differs in one important aspect, namely in its location. ... Phosphorylation Cascade ATM Kinase I pS3 p53-Panbsp;...

Title:The Biochemistry of Cell Signalling
Author: Ernst J. M. Helmreich
Publisher:Oxford University Press, USA - 2001

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